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Remove skin, if any, from salmon.
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Using two forks, shred the salmon apart into pieces.
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In a large bowl, add salmon pieces, panko crumbs, red pepper, parmesan cheese, egg, lemon juice, red pepper flakes, garlic powder, salt, and pepper.
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Combine really well.
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Separate the mixture into 4 equal parts and form into patty shape.
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Let patties sit for 10 minutes.
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Heat olive oil in a skillet over medium low heat.
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Depending on skillet size, add burgers all at once or in batches, making sure not to overcrowd burgers.
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Cook for 4 minutes on each side.
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Remove and add desired toppings to patties.
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For lime sauce - combine 1/4 cup plain greek yogurt with zest and juice of one lime. Stir until combined. Use immediately or store in air tight container for up to 3 days.